Hello. Sign In
Standards Store

Biological Concepts and Techniques in Toxicology: An Integrated Approach

2006 Edition, March 6, 2006

Complete Document

Detail Summary

Active, Most Current

Additional Comments:
ISBN: 978-0-8247-2979-0
Price (USD)
Add to Cart

Product Details:

  • Revision: 2006 Edition, March 6, 2006
  • Published Date: March 6, 2006
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 411
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


Toxicology is a rapidly developing discipline whose advances are often based on utilizing concepts and techniques developed from basic biomedical research. Earlier revolutions in molecular biology and mathematical modeling have led to routine use of in vitro models and toxicokinetics developed from these disciplines. In order for toxicology to remain current and continue making significant advances, it is important that the latest developments be presented in a context focused on how they can be applied to different fields of investigation. How do concepts and new paradigms migrate into routine practice? Several recent toxicology issues have engendered attention and are deserving of a review that illustrates how new techniques have been applied to actual problems of toxicological interest. How did these migrate from the basic science laboratory to routine toxicology test protocols? How will today's revolution in the ‘‘-omics'' affect the practice of toxicology in the next decade? This book is meant to provide a timely introduction to these techniques focused on how the latest science can be applied to existing problems in toxicology. It is also meant to overview some recent areas where progress has been made and a story can begin to be told.

The initial chapters review new approaches or concepts that will have a major impact on the practice of toxicology in the coming decade. These include the ‘‘omics'' which together comprise systems biology as well as mathematical approaches designed to link chemical structure to activity. This section ends with a cogent presentation of hormesis, a concept that has begun to alter the way toxicologists and others interpret dose–response relationships, the cornerstone to the practice of classical toxicology. The four chapters comprising the next section of the book deal with how biological data and test systems are integrated into the actual practice of toxicology. What is the validation process that allows a novel idea to become a standard test? The final section of chapters reviews applications of toxicology to specific and more focused topics that represent current issues facing society today, including discussions of genetically modified food, nanomaterials, and pharmaceutics. Specific disciplines, including inhalational and forensic toxicology are discussed, as are current military issues that continue to draw attention.

The goal of this book is not to reproduce comprehensive toxicology texts covering basic mechanisms of toxicity or target organ toxicology; nor is it a methods text overviewing the nuts and bolts of new techniques. The goal is to highlight new methods and concepts that may have a major impact on toxicology and present how such concepts and techniques migrate into the mainstream of toxicology.