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Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions

2012 Edition, September 17, 2012

Complete Document

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Active, Most Current

Additional Comments:
ISBN: 978-1-4398-7211-6
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Product Details:

  • Revision: 2012 Edition, September 17, 2012
  • Published Date: September 17, 2012
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 463
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


While acute inflammation is a healthy physiological response aimed at wound healing, chronic inflammation has been directly implicated in a wide range of degenerative human health disorders. These pathologies encompass almost all of present-day noncommunicable diseases such as obesity, diabetes, atherosclerosis, and high blood pressure, as well as cancer. Thus, the February 23, 2004, cover of TIME magazine featured inflammation as "The Secret Killer." To preserve good health, it is important that we are capable of rapidly mounting an inflammatory response to tissue injury. It is also equally important that such inflammation be resolved in a timely manner such that the state of chronic inflammation is averted. Lifestyle factors such as diet, stress, tobacco, obesity, infection, and pollutants are known to contribute to chronic inflammation. Prudent nutritional and exercise habits are powerful tools to fight chronic inflammation.

In this volume, the following three sections provide cutting-edge and comprehensive treatment of the process and factors that influence chronic inflammation.

(I) Systems Biology of Inflammation and Regulatory Mechanisms (Chapters 1–10)

(II) Pathologies Associated with Inflammation (Chapters 11–18)

(III) Nutrition & Therapeutics for Inflammatory Diseases (Chapters 19–28)

Section I addresses the understanding of the process of chronic inflammation including initiation, progression, and resolution. Section II includes a rigorous and critical treatment of specific human health disorders where chronic inflammation plays a major role. Section III discusses countermeasures for protection including nutritional and other interventions. Protective abilities of structurally diverse antioxidants, phytochemicals, anti-inflammatory diets, omega-3 fatty acids, NSAIDs, disease-modifying antirheumatic drugs, and novel regimens have been extensively discussed by authoritative experts in the discipline.

We extend our special thanks to Randy Brehm and Jill Jurgensen at Taylor & Francis for their continued support and help for putting this volume together. It has been a rewarding experience to interact with the generous authors who were enthusiastic and willing to contribute to this volume. We hope you enjoy this volume as much as we have enjoyed putting it together.