Hello. Sign In
Standards Store

Clinical Pathology of Urological Tumours

2007 Edition, October 24, 2007

Complete Document

Detail Summary

Active, Most Current

Additional Comments:
ISBN: 978-0-203-08983-5
Price (USD)
Add to Cart

Product Details:

  • Revision: 2007 Edition, October 24, 2007
  • Published Date: October 24, 2007
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 266
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


Since 1890, when in Paris urology became a separate course of study from general surgery, this speciality has developed into a field of medicine in which science, technical developments, diagnostic procedures, and invasive as well as non-invasive therapeutic measures have reached their highest levels. Urologic admissions and surgical procedures are among the most frequently performed interventions in current hospital care. In 1992, a century later, pathologists dealing with urologic problems founded an international society of this subspecialization. Long before, however, outstanding pathologists on both sides of the Atlantic devoted their lives to the study of urologic disease, mainly tumors arising in the genitourinary system. Pathologists and urologists have learned in recent decades to discuss very openmindedly the common issues and have achieved in many institutions an exemplary degree of reciprocal understanding. The cooperation is not limited to daily diagnostics but rather, extends to common scientific approaches and work.

The efforts of the uropathologists led to new generally accepted WHO classifications of urologic tumors, which are indispensable for therapy planning and for the comparison of the results among different institutions. Many of the new morphologic tumor classifications are already based on knowledge achieved through new methods, which allow the pathologists to analyze chromosomes and genes as well as their aberrations and mutations even in the ‘dead' cells of paraffin-embedded tissue. Alterations of the tumor cell genome are entering into daily pathologic routines and will in the near future permit a more individual therapeutic approach. Nevertheless, at present surgery is still the first and most important procedure in the basic therapy of urologic tumors and biopsy the most important diagnostic approach (1 million prostate biopsies worldwide!). Even for chemotherapy treatment, morphology is used for the choice of drugs and for the assessment of their effectiveness.

This book is not intended as a ‘workbench' book or an atlas for pathologists – there are numerous outstanding publications dealing with the pathologic diagnostic of single genitourinary organs. Its objective is to give urologists and other interested clinicians an overview of the morphology of the tumors of the genitourinary system. The international classifications, grading, and staging procedures which are included, as well as the rules for sampling and handling of the biopsy and surgical specimens, should permit a better understanding of the morphologic assessment of the tumor diseases. The uses of modern morphologic techniques for differential diagnostic purposes are presented in order to show clinicians what the current possibilities and limits of a pathologic diagnosis are.

A book written by many authors has both weaknesses and strengths. We take into account that the single chapters differ in style, which may disturb some readers. Yet we regard this also as a strength because the very personal approach of the authors reflects their longstanding diagnostic and scientific careers, which have undergone much scrutiny and testing at international congresses and classification committees, and in scientific papers and books. Moreover, tumors of the genitourinary system cannot be compared with those of other systems. Gastrointestinal tract tumors, for example, have a very similar morphology and prognostic assessment observes the same rules for all single segments. Prostate and testis tumors do not have anything in common except the gender of the patients. The bare history of the grading of bladder cancer, which has changed three times in the last 10 years, would deserve its own chapter. Kidney tumors are the first example of a classification based on the karyotype of the tumor. Tumors of the adrenals are still a diagnostic problem because they are so rare. Last but not least, the penis carcinoma, which is practically unknown in Europe and the US, requires an expert who confronts this problem daily.

On behalf of all the authors, I venture to extend a debt of gratitude to all those anonymous colleagues and friends who with their comments and questions have enlarged and enriched our experience. I also thank all our partners who over the last few months spent their evenings alone, even more frequently than usual.