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Copper and the Skin

2006 Edition, August 15, 2006

Complete Document

Detail Summary

Active, Most Current

Additional Comments:
ISBN: 978-1-4200-0943-9
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Product Details:

  • Revision: 2006 Edition, August 15, 2006
  • Published Date: August 15, 2006
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 328
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


Metals have long interested the dermatologic community in terms of their toxicity and efficacy. A century ago, mercury enjoyed widespread usage in the treatment of syphilis.

As the dermatologic sciences evolved, sufficient knowledge also evolved, leading to the clear assertion that metals may be toxic when applied to the skin. Nickel has enjoyed the greatest amount of study, especially because of its frequent induction of clinical allergic contact dermatitis in humans. Cobalt is also a common contact allergen, but its clinical significance is less clearly explored. Chromate in cement, leather, and other applications also enjoys considerable study. Most recently, gold salts have been recognized as a common inducer of cell-mediated immunity; however, this clinical significance is currently being investigated in terms of dermatitis and even restenosis.

These data have led to several textbooks dedicated to individual metals. The first was on chromate (by Desmond Burrows), many metals and the skin (by R. Guy and J. J. Hosty´nek), and most recently nickel (by J. J. Hosty´nek and H. I. Maibach). The current volume on copper presents sufficient information to place it among the pantheon of the metallic gods and dermatology.

Our aim was to mold contributions from individuals widely spread over several disparate disciplines into a cohesive, readily digestible text. The individual disciplines include basic chemistry (metallurgy), dermatotoxicology (irritant and allergic contact dermatitis), and membrane transport (percutaneous penetration).

Our specific objective is to allow scientists in many fields to more efficiently focus their attention on this essential element (copper) and the skin. Hopefully, the parts will simplify understanding the whole.

This volume differs from the others, not only in its extensive dermatotoxicologic profile of copper and its salts, but also as an equally impressive data on copper's possible anti-inflammatory actions in man.

The editors welcome suggestions for the next edition.