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Diagnostic Lymph Node Pathology

2nd Edition, January 28, 2011

Complete Document

Includes all amendments and changes through Change/Amendment , January 28, 2011

Detail Summary

Active, Most Current

Additional Comments:
ISBN: 978-0-340-99068-1
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Product Details:

  • Revision: 2nd Edition, January 28, 2011
  • Published Date: January 28, 2011
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 178
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


Although it is only four years since this book was first published, our understanding of the biology and pathology of malignant lymphomas, and consequently the way we interpret lymph node biopsies, has changed to the point where a new edition has become necessary. An additional stimulus has been the publication of a new edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, in which a number of new entities are recognized, and some regrouping has taken place.

Our main aims remain the same: to provide general histopathologists and trainees with a systematic and logical way of approaching lymph node biopsies; to help them use diagnostic techniques wisely, in particular the bewildering variety of antibodies now available for immunohistochemistry; and to guide them through the maze of differential diagnoses, enabling them to reach an accurate diagnosis. If specialized haematopathologists are tempted to keep a copy hidden in a desk drawer for quick reference we would be more than gratified. We recognize the important role molecular techniques now play in providing supporting evidence, but, as before, the emphasis throughout is on morphology, supplemented by immunohistochemistry.

It is easy to become excited by new entities and concepts. While including these, we hope we have managed to preserve the balance of the text, without giving undue prominence to rarities. At the same time, we have attempted to provide a reasonably complete guide to lymph node pathology, so that the answer to most diagnostic problems will be found in these pages. We should emphasize that this is not a comprehensive guide to malignant haematopathology: only those conditions that involve lymph nodes, either primarily or secondarily, are discussed. This inevitably means that some important conditions, for example some forms of extranodal T-cell lymphoma, are either not considered or receive only brief mention.

The general format of the book has been retained and the layout has, we think, been improved. For quick reference, the boxes containing concise clinical, morphological and immunohistochemical features of each entity have been preserved and updated. A number of illustrations have been replaced and additional ones included. The layout of the illustrations has been changed to avoid boxes that overflow onto two pages, a major criticism of the previous edition. The references given are by no means comprehensive. We have included those that we regard as being seminal, useful reviews or evidence of recent significant advances, and we hope the interested reader will find these a useful starting point.

Since the previous edition the use of needle core biopsies has increased substantially. In expert hands, they provide a rapid and increasingly reliable means of diagnosis, with minimal inconvenience and discomfort for the patient. Chapter 11 has been expanded to reflect this and to provide a guide to their interpretation and limitations.

We hope our efforts have resulted in a useful and practical guide to a subject that remains endlessly challenging and fascinating.