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DIN EN 16418

2014 Edition, July 1, 2014

Complete Document

Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)

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Product Details:

  • Revision: 2014 Edition, July 1, 2014
  • Published Date: July 2014
  • Status: Active, Most Current
  • Document Language: English
  • Published By: Deutsches Institut fur Normung E.V. (DIN)
  • Page Count: 22
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:

This European Standard specifies a test method for the laboratory assessment of the potential cytotoxic effect of paper and board intended to come into contact with foodstuffs using specifically the HepG2 cell line.

Compared to the EN 15845[1], HepG2 cells are more representative of a human oral exposure to xenobiotics, due to the presence in the cells of phase I, II and III enzymes of the metabolism.