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Drug Delivery: Engineering Principles for Drug Therapy

2001 Edition, March 15, 2001

Complete Document

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Active, Most Current

Additional Comments:
ISBN: 9780195085891
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Product Details:

  • Revision: 2001 Edition, March 15, 2001
  • Published Date: March 15, 2001
  • Status: Active, Most Current
  • Document Language: English
  • Published By: Oxford University Press (OUP)
  • Page Count: 384
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


I spend my professional life exploring an intersection of three worlds: chemistry and biology and engineering. This is not always an easy neighborhood, but it is exciting without fail. My own experience suggests that chemical and biomedical engineers adapt easily to life in this niche. But I also believe that individuals working or studying in departments of materials science, pharmaceutics, pharmacology, biology, chemistry, and others may also find this subject matter-if not necessarily this particular treatment-of interest. Therefore, I have tried not to assume too much previous experience; many of the subjects include essential background directly in the text. In a few cases I have omitted detail and provided references, particularly in those cases where good and accessible references exist.

Synthetic materials present a tremendous potential resource in treating human disease. For the rational design of biomaterials, an understanding of polymer chemistry and polymer physics is necessary, but not sufficient. Equally important is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This is the point of the present book: to provide a working foundation in these principles, which I hope you will carry forward into the development of useful methods for drug delivery.

I am grateful to many individuals for encouraging me and facilitating my effort to produce this text. I thank Bob Langer for his unsinkable enthusiasm, and for introducing me to the concepts that underpin this work. I thank Doug Lauffenburger for inciting my interest in authorship, for lending advice and encouragement at critical junctures, and for providing (in his own text) an exceptionally strong example to follow. I thank Mark McHugh and Michael

Shuler for being general sources of inspiration. I thank William Deen, instructor for the first class I took in the field of biomedical engineering, for introducing me to many of the problems surveyed here. I thank Nadya Belcheva, Alison Fleming, Melissa Mahoney, and Jian Tan for reviewing early versions of several chapters and Rupa Patel and Christopher Anker for their careful and thorough reading of the penultimate draft. I thank Claude Cohen for his insightful review of Chapter 4 and Rebecca Willits for assisting with the preparation of Chapter 10. I thank Alexander for his good-natured assistance with the index. And I thank the many students of my courses at Johns Hopkins and Cornell who suffered through early and late (but always incomplete) drafts of this text.