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Itch: Basic Mechanisms and Therapy

2004 Edition, January 6, 2004

Complete Document

Detail Summary

Active, Most Current

Additional Comments:
ISBN: 978-0-8247-4747-3
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Product Details:

  • Revision: 2004 Edition, January 6, 2004
  • Published Date: January 6, 2004
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 428
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


For many years progress in understanding the neuropathophysiology and molecular basis of itch has been handicapped by a lack of specific and sensitive investigational methodologies for human subjects and the unsuitability of animal models. Researchers have finally begun to overcome these difficulties, with important clinical implications. Recent neurophysiological research has made possible a more accurate description of neural pathways of itch and has confirmed the distinctiveness of itch pathways in comparison with pain pathways.

We were motivated to work on this book by consideration of patients afflicted by chronic and intractable itch and our desire to contribute to a better understanding of this common, bothersome symptom. The idea was proposed in October 2001 at the International Workshop for the Study of Itch in Singapore. This was the first multidisciplinary meeting that brought clinicians and scientists together to address problems related to itch.

This book presents a concise discussion of the basic aspects of itch, various diseases in which itch constitutes a major problem, and methods employed in its diagnosis and management. It is designed to be a source of information for both dermatologists and nondermatologists who treat itch, as well as for researchers in the field of neurophysiology and pharmacology. The organization of the chapters reflects our views as to how the reader can best utilize these materials. The book has six parts. Part I contains a proposed clinical classification of itch, based on an improved understanding of its neurophysiology. Part II reviews the basic mechanisms of itch. Part III addresses the evaluation of the patient with itch. Part IV focuses on epidemiology and characteristics of itch in skin and systemic diseases. Part V provides an overview of the different methods for the treatment of itch currently in use or in clinical trials. The last part consists of three chapters addressing the social and psychological aspects of itch.

The authors were selected for their expertise and interest in this field. While efforts were made to avoid repetition, each author was free to present his or her own concepts and thoughts. The progress documented in this book is encouraging and is a direct result of expanded interest in the problem of itch in both the scientific and clinical communities.