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Pathology of Melanocytic Disorders

2nd Edition, September 28, 2007

Complete Document

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Active, Most Current

Additional Comments:
ISBN: 978-0-340-80968-6
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Product Details:

  • Revision: 2nd Edition, September 28, 2007
  • Published Date: September 28, 2007
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 491
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


Fifteen years have elapsed since the publication of our Biopsy Pathology of Melanocytic Disorders. In that long period, a large number of relevant articles have appeared and have necessitated not only a major update, but also, inevitably, an increase in size of the book. New nevus variants have been described; the picture of dysplastic nevus syndrome and the nevi occurring in that context have been clarified in several respects; new immunomarkers of melanocytic lineage have become available; the melanoma sentinel node biopsy has not only gained increasing acceptance and provided new opportunities but has also raised new questions; a new American Joint Committee on Cancer (AJCC) melanoma staging system has been launched and assessment of melanoma prognosis has significantly benefited from this; rare melanoma variants with low-grade malignant potential have been identified; extracutaneous tumors with some melanocytic properties have been described; and molecular techniques of detection of minimal residual melanoma have been put forward and are currently under intensive study. Together, these developments have produced major changes in the standard of surgical pathology of melanocytic tumors today.

Like many of our colleagues, burdened with an everincreasing bulk and complexity of work, we have mixed feelings about expanding benchbooks, and therefore we have made every attempt to keep the book practical and useful, as a detailed review and text for quick reference. We have spent much time and thought on the summary tables, the illustrations, and the index. In this respect, a special word of thanks is due to Mr J T Veldhuisen and Mr R Otsen, medical photographers at the Pathology Department, VU Medical Center, Amsterdam. As standardization and consensus is rightly gaining ground in diagnostic pathology, we have included consensus guidelines and recommendations on the diagnosis and staging of melanoma.

We have again been fortunate in receiving countless helpful comments and suggestions from many colleagues, nearby and at a distance. We are deeply grateful to our colleagues, Drs C D M Fletcher (Boston, Massachusetts), R Folberg, R M DeMay, and P Gattuso (Chicago, Illinois), A L Folpe (Rochester, Minnesota), J M Kros (Rotterdam), M J Jager, D de Wolff-Rouendaal, and P C W Hogendoorn (Leiden), D Troost, J L Peterse, I van der Waal, and E H Jaspars (Amsterdam), M R Canninga-van Dijk (Utrecht), D Hayes (Arnhem), L M Sterk (Enschede), and A T Evans (Dundee) for access to unique slides of rare entities, specifically for the purpose of illustration in this book. A further indispensable source of materials and data has been provided by the many thousands of cases which we have received in consultation, sent to us by so many colleagues that we can only apologize for not listing their names here.

Finally, our warmest and heartfelt thanks are, as always, due to our dear wives: Hanneke and Zsuzsa. When the going gets rough, as it always does in the final climactic phases of an undertaking like this, they provided the encouragement and the companionship, without which this work would not have been achieved. It is to them, again, that we dedicate this work.