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Reproductive Toxicology

3rd Edition, September 20, 2010

Complete Document

Detail Summary

Active, Most Current

Additional Comments:
ISBN: 978-1-4200-7344-7
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Product Details:

  • Revision: 3rd Edition, September 20, 2010
  • Published Date: September 20, 2010
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 422
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


This third edition of Reproductive Toxicology is a collaborative effort by the authors and editors to capture our rapidly growing understanding of reproductive and developmental biology and toxicology from the level of molecules to gametes to adult organisms. This explosion of information is made possible by integrative approaches (e.g., systems biology, in silico initiatives), new areas and technologies (e.g., genomics/ genetics, epigenetics, proteomics, and metabolomics), new methodologies and applications, etc. We are beginning to understand the regulatory processes involved in the exquisite, orchestrated processes of male and female development in terms of reproductive structure and functions and the coordinated development of the major organ systems. The chapters cover the normal and abnormal development and function of the reproductive systems of males and females, the processes involved in pregnancy, fertilization, and development of the central nervous, cardiovascular, renal, respiratory, immune, and the endocrine systems. We also focus on the consequences of exposures to toxic substances during vulnerable life stages on the development, structures, and functions of these biological systems. These chapters also include epigenetics, -omics, and metallic environmental factors in reproduction and development.

We have included overviews of the national and international governmental regulatory agencies, which provide oversight (testing guidelines, technical guidance, etc.) for pharmaceuticals by the Food and Drug Administration (FDA) and the International Conference on Harmonization (ICH, United States, Japan, and European Union), and for pesticides and commodity chemicals by the Environmental Protection Agency (EPA), Office of Prevention, Pesticides and Toxic Substances (OPPTS), and the Organization for Economic Cooperation and Development (OECD), now including over 26 countries (including the United States, Japan, European Union, etc.). We also included an overview of Investigative New Drug (IND) submissions to the FDA.

We fervently hope (and expect) that the expertise, insight, and excitement in the content of these 20 chapters on our accelerated acquisition of knowledge and clear understanding of reproductive toxicology (which the authors have conveyed so well) will inspire our readers, as they have us, the editors of this book.