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Respiratory Control and Disorders in the Newborn

2003 Edition, January 28, 2003

Complete Document

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Active, Most Current

Additional Comments:
ISBN: 978-0-8247-0984-6
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Product Details:

  • Revision: 2003 Edition, January 28, 2003
  • Published Date: January 28, 2003
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 631
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


Since the inception of this series, several volumes have been devoted to respiratory control. These contributions have critically reviewed the experimental evidence (beginning with the observation by LeGallois) that the respiratory center is located in the medulla. Until now, respiratory control in the newborn has been a small part of the general discussion of respiratory control. In recent years, the increasing interest in developmental neurobiology—more specifically, our quest for understanding the cellular mechanisms involved in the control of breathing— has put our knowledge of respiratory control disorders on a firmer footing. These cellular events are complex and often show marked developmental changes. Interpretation and integration of these cellular events into the system levels are necessary for better understanding of the pathophysiology of various respiratory control disorders, and, in turn, targeted therapeutic interventions can be developed. An excellent example of this undertaking is the discovery of surfactant deficiency as the underlying cause of respiratory distress syndrome in premature infants, and the subsequent development of natural and synthetic surfactants to treat this ‘‘developmental disorder.'' We hopefully anticipate the development of drugs specifically targeted to enhance maturation of respiratory control in premature infants and the rectification of abnormal cellular properties through molecular genetics technology.

This volume is devoted to the disorders of respiratory control in the newborn. To refresh and enhance our understanding of respiratory control, the first part deals with respiratory control in the normal newborn. Several chapters in this section address the relevant topics critically, in the fetus and the newborn, at both the system and cellular levels. These include chapters on development of respiratory control, gasping, and neural and chemical control of breathing. This section also features chapters on development of sleep states and metabolism— two vitally important factors in determining respiratory output.

The second part, which focuses on respiratory control disorders, begins with an overview. The diagnosis of these disorders in the neonate often begins with cardiorespiratory monitoring in the neonatal intensive care unit. An examination of the pros and cons of the cardiopulmonary monitoring techniques used in the neonate follows. The main focus of this part is apnea of prematurity; several chapters are dedicated to this clinically important topic. Congenital central hypoventilation and neuromuscular syndromes are examined next, followed by chapters on control of breathing in acute and chronic respiratory failure. A discussion of the maturational aspect of the respiratory control mechanisms sets the stage for the final chapter, which addresses modifiable risk factors in sudden infant death syndrome.

I would like to thank this outstanding group of international contributors for their comprehensive, critical, and up-to-date chapters.