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Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and Engineering

2007 Edition, February 12, 2007

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Active, Most Current

EN
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ISBN: 978-0-8493-9815-5
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Product Details:

  • Revision: 2007 Edition, February 12, 2007
  • Published Date: February 12, 2007
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 498
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:

Preface

Spinal fusion remains at the center of many reconstructive procedures of the spine. However, several new concepts have recently emerged, which led many spine surgeons to rethink traditional approaches to common clinical problems. Examples of these new trends include use of artificial disc replacements for reconstruction of degenerated spinal segments instead of interbody fusion devices, percutaneous pedicle screw fixation systems instead of open screw placement, and minimal invasive decompressions through small percutaneously placed tubes instead of open, wide laminectomy procedures through large incisions. Minimally invasive techniques are now aided by computerized navigation systems; substitute, and expander materials are increasingly employed as adjuncts to autologous bone grafts; and growth factors, such as BMP-2, are now strongly considered as a replacement material for iliac crest bone grafts.

With the ongoing expansion and aggressive marketing of novel spinal device and implant systems, judging many of the newer developments presents a growing challenge to clinicians as it is not clear whether all of these innovative concepts represent true improvements over established clinical standards of care. Extensive work is currently underway to study the healing success and decrease in morbidity with less rigid implant systems, more bioactive and mechanically sound bone graft substitutes, and growth factor applications to establish clinical outcomes and rates of failure.

The illustrative description of the development of a new generation of materials and devices capable of specific biological interactions to improve reconstruction of the spine and to enhance reconstitution of diseased spinal segments are at the heart of this new reference text: Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and Engineering. Improvement of these materials and devices is in a constant state of activity, with the challenge of replacing older technologies with those that allow better exploitation of advances in a number of technologies; for example, motion preservation; navigation; less rigid, biologically active, and/or biodegradable implants that exert less stress to adjacent levels; drug delivery; recombinant DNA techniques; bioreactors; stem cell isolation and transfection; cell encapsulation and immobilization; and 3D scaffolds for cells. The chapters within this text deal with issues in the selection of proper technologies that address biocompatibility, biostability, and structure/function relationships with respect to specific clinical problem scenarios. Other chapters also focus on the use of specific biomaterials based on their physiochemical and mechanical characterizations. Integral to these chapters are discussions of standards in analytical methodology and quality control.

The readers of Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and Engineering will find it derived from a broad base of backgrounds ranging from the basic sciences (e.g., polymer chemistry and biochemistry) to more applied disciplines (e.g., mechanical/chemical engineering, orthopedics, and pharmaceutics). To meet varied needs, each chapter provides clear and fully detailed discussions. This in-depth but practical coverage should also assist recent inductees to the circle of spinal surgery and biomaterials. The editors trust that this reference textbook conveys the intensity of this fast-moving field in an enthusiastic presentation.