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Thrombus and Stroke

2008 Edition, June 24, 2008

Complete Document

Detail Summary

Active, Most Current

Additional Comments:
ISBN: 978-0-8493-4196-0
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Product Details:

  • Revision: 2008 Edition, June 24, 2008
  • Published Date: June 24, 2008
  • Status: Active, Most Current
  • Document Language: English
  • Published By: CRC Press (CRC)
  • Page Count: 244
  • ANSI Approved: No
  • DoD Adopted: No

Description / Abstract:


Stroke is no longer an untreatable or unpreventable condition. The management of stroke is changing rapidly as new developments appear for acute treatments, rehabilitation, and secondary prevention. In particular, it has been clearly demonstrated that patients with acute stroke need rapid assessment at the hospital following the onset of symptoms to be eventually treated with intravenous, intra-arterial, or combination reperfusion therapy. Admission of stroke patients to specialized Stroke Units, with physicians specifically trained to treat stroke, improves their outcome. Hopefully in the near future, Stroke Units will be present not only in tertiary care centers but also in community hospitals.

With regard to primary and secondary stroke prevention, many potential candidates for anticoagulation still fail to receive appropriate treatment. To achieve effective prevention of stroke, more efforts should be spent on education to increase the number of treated subjects. Nevertheless, the widespread use of antiplatelet and cholesterol-lowering agents as well as the aggressive management of risk factors are shown to be effective in preventing stroke and improving outcomes. Epidemiological studies suggest that reducing the prevalence or shifting the distribution of risk factors across the entire population can be expected to reduce significantly the incidence of stroke, as is the case with coronary heart disease.

Further advances in stroke treatment will include combination therapies. The successful design of future drug therapies will result from a more complete understanding of not only the activity of these agents on platelet function and the coagulation cascade but also of their effects on the endothelium and within the brain parenchyma.

Why have we chosen to launch this publication when so many other publications on cerebrovascular disease and stroke are readily available?

The concept behind this volume is to integrate the basic science of clot formation and thrombolysis into the daily clinical practice of acute stroke treatment.

The first part of the volume provides an overview of how a clot forms, giving a brief review of the coagulation cascade at a cellular level and the interaction between clot formation/breakup and the flowing blood. Subsequently, research stroke models are evaluated for their use in basic and translational research. A chapter on assessment of thrombogenicity of vascular implants such as stents and grafts follows that we thought may be of use for the development of future implantable devices for stroke treatment.

The clinical implications and importance of the subject as it relates to stroke are then reviewed in the second part of the book. The latest methods of imaging stroke are surveyed. A chapter on immediate and chronic intervention in stroke follows. The most recent developments in endovascular treatments of ischemic stroke are summarized in the next chapter followed by a discourse on neuroprotection. Finally, the last chapter discusses the multimodality approach to acute stroke treatment.

We have on our panel a group of specialists who have through their dedicated efforts brought in the latest information about their subspecialty. We hope you will enjoy reading this inaugural issue. We also welcome your comments and suggestions to create an open forum for further discussion.

This book is being targeted at both basic scientists and clinicians who require a review of this subject, without the detailed descriptions found in other texts. This volume will allow the reader to formulate a basic understanding of what a clot is, how it forms, the clinical aspect of the problem, and the latest available treatment options in acute stroke.

We would like to thank all of the contributors involved in the production of this volume. Our special thanks go to the editors at Informa Healthcare, specifically to Dana Bigelow, the book development manager, Brian Kearns, the project editor, and Tintu Thomas, the typesetter. We also wish to thank Sandra Beberman, VP and managing director, US Books and Journals acquisitions, Chris DiBiase for the cover design, and Melissa King, our marketing manager. We would also like to express our thanks to Dagmar Schnau for editorial work in the early stages of the project.

I would like to thank Veronica, Albert, and Nathan for their love.